"A visitor" and "their/them" do not agree. The easiest solution is to make the noun plural ("visitors"); otherwise the pronouns should be singular ("his/him" or "her/her").
2. Capitalization:
"Southeast Asia" is a proper noun, so it needs to be capitalized.
3. Modal + verb:
After a modal such as "must", use the verb name, not the infinitive (i.e. "must remember").
4. Infinitive/gerund:
In this sentence, since it is not a matter of remembering something from the past, the correct form after "remember" is the infinitive (i.e. "remember to take").
5. Word form:
Since "regular" modifies "take", it needs to be in the adverbial form ("regularly").
6. Word confusion:
The word we need here is "effective" not "affective".
7. Missing words:
The words "for it" are missing after "regularly", and the word "at" is missing before "preventing".
8. Parallel construction:
The conjunction "and" joins two phrases that are objects of "preventing", so they should be parallel. Here is one possibility: "preventing them from getting sick" and "spoiling their trip".
9. Word form:
We often use the phrase "anti-malaria medicine", but since "anti-malaria" is modifying a noun, it should be in the adjectival form ("anti-malarial").
Visitors to Southeast Asia must remember to take their anti-malarial medicine regularly for it to be effective at preventing them from getting sick and spoiling their trip.
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